In 1503, Leonardo da Vinci was given a commission to create a portrait of Francesco del Giocondo's wife, Lisa Gherardini. He began work this year, and continued working on it until his death in 1519. It is believed that an assitant also painted the Mona Lisa del Prado in conjunction with the original, copying the original painting. 

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circa. 1503 to circa. 2 May 1519

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