In Rome is where Victor's creation observes the De Lacey family. He stays there outside of their home and watches them, that is how he learns how to speak. One day he goes inside the house to talk to the blind father but when the children come home he is beaten and runs off. This place is of significance because it was in association with the uprising of new ancient societies and the decline of others, which could parallel the creation's life because he was made and had to find a place in the world. The British had mixed feelings about Rome in the 1800s, with a strong respect for its classical past and a strong mistrust of its contemporary Catholic identity. The imperial era, religious conflicts, and the experiences of Grand Tour travelers all influenced British ideas. I learned that the British had a lot to think about Rome during this time. I also did not know that there was that much significance. 

https://study.com/academy/lesson/setting-in-frankenstein-by-mary-shelley.html#:~:text=What%20is%20the%20main%20setting,the%20De%20Lacey%20family's%20home.

https://jamescungureanu.com/2014/10/15/anti-catholicism-in-nineteenth-ce....