The wars in Lombardy were a series of struggles between the Republic of Venice and the Duchy of Milan, leading to the five major Italian territorial powers that make up the map of Italy until the Italian Wars (i.e., Venice, Milan, Florence, Naples, and the Papacy). The wars ravaged the economy of Lombardy and weakened the power of Venice. The Peace of Lodi in 1454 brought 40 years of comparative peace to Northern Italy. This is the time of the Medici rule of Florence, first Cosimo de’ Medici, then Piero “the Gouty,” then Lorenzo Il Magnifico.  The death of Lorenzo marked the end of the Golden Age of Renaissance Florence. Both Leonardo da Vinci and Michelangelo Buonarroti were active (and tied to Lorenzo) during this period. In 1428, Venice acquired Brescia and Bergamo as a result of this struggle.