The location of Pope's villa on the bank of the Thames, a few miles from Hampton Court. In Pope's time, Twickenham was a village west of London where many rich Londoners had houses. He makes a few references to it in his Epistle to Dr. Arbuthnot (1735), particularly in reference to how even his own home seems unable to isolate him from the masses of critics and admirers. Pope built a tunnel under a road to connect his main garden with his villa. In part of this tunnel, he constructed his now famous grotto, which he decorated with shells and mirrors (see line 8).
What walls can guard me, or what shade can hide?
They pierce my thickets, thro' my Grot they glide; (7-8)
All fly to Twit'nam, and in humble strain
Apply to me, to keep them mad or vain. (21-22)