The Clock in St. Mark's Clocktower is an excellent example of the development of clockwork over the years. Inaugurated in 1497, it used weights and a Verge and Foliet escapement, and showed the 24 hours of the day (Italian style), the relative positions of 5 planets, the moon's phases, and the position of the sun in the zodiac. It required a clock-keeper to manage and maintain the clock.

The Madrid Codices, written by Leonardo da Vinci, were discovered in this library. The first codex was finished during 1490-1499 and the second was finished during 1503-1505.

Where the first quartz wristwatch was developed. It is registered on the List of the Institute of Electrical and Electronics Engineers (IEEE) Milestones as a key advance in Electrical Engineering.

This is where the first quartz clock was developed by Warren Marrison.