A short time after arriving, the Gang arrives at the Colorado River, they have a new plan of attacking and robbing those who cross the river, taking their gold. The Gang betrays and kills a group of Yuma Native Americans. This will be the future cause of their downfall.

Weeks later after the killings, a band of Yuma Native Americans strike back, killing most of the Glanton Gang in their holdout at the Colorado River. The Kid and Tobin manage to escape.