Galata, also known as Pera in historical documents, is a neighborhood of Turkey that is across from Istanbul. These two areas are separated by the Golden Horn, an inlet and major waterway that flows into the Bosphorus. From the 10th century onward, Galata served as a trading hub for foreign traders. However, the geography of the Golden Horn impeded trade and travel to the East. During da Vinci’s time, a pressing engineering problem was how to connect these two areas across the Golden Horn, facilitating the movement of goods, people, and ideas.

San Salvi is a Church that orginally commisioned and held the painting "The Baptism of Christ". The Church was built in the 1000's as part of an abbey and destroyed partially in the 1500's. It was rebuilt and used as a monastary during the renaissance era. 

The Uffizi Gallery is one of the largest and most important Italian museums, storing a collection of priceless works of art from the Italian Renaissance and beyond. Cosimo de’ Medici commissioned Giorgio Vasari to design the building in 1560. It’s original function was to house Florentine legal and administrative offices, with a private gallery for the collections of the Medici family on the second floor.

The Republic of Florence, Leonardo da Vinci's birthplace and childhood home, played a large role throughout da Vinci's career.