Cologny
Cologny is known as the birthplace of Frankenstein, where Lord Byron had actually rented a mansion named the Villa Diodati in 1816. Mary and Percy Shelley, and Claire Clairmont were staying nearby, and all told ghost stories which resulted in a challenge to write a Ghost Story. This timeframe was also known “The Year without a Summer”, so much time was spent indoors writing.
South America
South America shows up in the story Frankenstein when the creation asks Victor to make him a companion. This pops up in chapter 17 when the creature locates Victor and they have this conversation. The creature promises that he will run away with a woman creation to South America. The British saw South America as a major economic opportunity in the 1800s, and after assisting the newly independent countries in separating from Spain and Portugal, they sought to establish open trade markets and make investments in these countries.
Edinburgh
In Chapter II of Volume III, Victor and Clerval arrived in Edinburgh during their tour of Britain and have very different reactions. Victor says "I visited Edinburgh with languid eyes and mind; and yet that city might have interested the most unfortunate being." (Vol. II Chapter II) which in my opinion basically means that Edinburgh would be incredibly impressive to anyone except Victor because he is too wrapped up in guilt and dread to appreciate it. Instead of admiring the city's beauty again Victor allows his internal struggles to make everything seem lifeless.


