In Elizabeth Gaskell's novel North and South, London is not just a geographical location, but also a powerful symbol of the socio-political and economic structures that govern Victorian Society. While the novel is set primarily in the industrial town of Milton, London plays an essential role in showcasing the broader scope of the changes happening across Britain during the Industrial Revolution.

Margaret's cousin, Edith marries Captain Lennox at the beginning of North and South (1855). Before the events of the book, Margaret lived with her aunt and Edith in London, before returning to her parents. After her wedding, Edith moves to Corfu, Greece where her husband is now stationed. They live here for most of the book, before returning to London. After Mrs. Hale dies, Mr. Hale encourages Margaret to visit Edith in Corfu to get away from Milton for some time, but she declines and stays with her father to care for him.