Florence, Italy is the birthplace of the period we now know of as the Renaissance Era. The Renaissance Era was a rebirth of European cultural, artistic, political, and economic values following the Middle Ages. This time period is associated with a shift in thinking in how humans perceive the world around them. During the Middle Ages, advances in science and art in Europe was not common. The Middle Age time period is sometimes branded as the "Dark Age" because of the lack of scientific and cultural advancement.

221B Baker Street is the fictional address of Sir Arthur Conan Doyle's Sherlock Holmes, introduced as the detective's address in the first Holmes novel A Study in Scarlet.

Lane, Kansas, is the present-day location in which the Pottawatomie Massacre occured, a pivotal event in the abolitionist cause preceding the Civil War in the United States. This was the location of the violent abolitionist event orchestrated by John Brown, a radical abolitionist, and very impactful character within the history of the Civil War, and general slavery in the United States. Lane, Kansas is a small town that lies along the banks of the Pottawatomie Creek on the eastern side of Kansas. 

In 1843, Isabella Baumfree became a devoted Methodist and felt that God called her to le